VCU Massey Cancer Center

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Cancer Cell Signaling

Program co-leaders

Sarah Spiegel, Ph.D.
Andrew C. Larner, M.D., Ph.D.

The Cancer Cell Signaling (CCS) program aims to elucidate the cellular and molecular signaling events that are dysregulated during neoplastic transformation and progression to develop methodologies that target these cancer-specific signaling events. 

Scientific goals

  • Examine the role of bioactive lipids in cancer cell signaling
  • Identify key signaling networks of cell growth, cell death, apoptosis, ER stress, and autophagy that are perturbed in cancer cells
  • Understand the interactions among metabolites, inflammation, bioenergetics, and the microenvironment that affect tumorigenesis

Achieving a greater understanding of cancer cell signaling helps Massey researchers identify potential therapeutic strategies and move them into preclinical testing. The ultimate goal is to develop rational bases for combining interventions using these targets in a patient-specific, precision medicine manner and to translate them into more effective therapeutics.

The CCS program has a strong commitment to training and fostering intra- and inter-programmatic interactions through regular program membership meetings, focused discussion groups with overlapping research interests, monthly seminars, and an annual retreat. These approaches have led to numerous collaborations that yield novel approaches and collaborative grants as funding sources.

View list of Cancer Cell Signaling members