Christina Tang, Ph.D.
Massey Cancer Center research program membership
Developmental Therapeutics
Department affiliations
Assistant Professor,
Department of Chemical and Life Science Engineering,
College of Engineering
Education
MS, North Carolina State University (2010)
PhD, North Carolina State University (2012)
Research description
We formulate polymer nanoparticles encapsulating chemotherapies using Flash NanoPrecipitation (FNP), a rapid, scalable method in which PEGylated block copolymers direct nanoparticle self-assembly. Leveraging new methods in self-assembly driven by tannic acid complex formation and hydrogen bonding, we have developed a pH labile nanoparticle platform. Paclitaxel, a common chemotherapeutic agent, was 5-fold more potent (as indicated by a decrease in inhibitory concentration) when encapsulated using our nanoparticle platform compared to free drug. We are currently studying the potency of drug combinations.
Disease focus of research
Breast, Prostate, Ovarian
Research keywords
Cancer therapy resistance,Targeted therapies
Published research (during tenure as a Massey Cancer Center member)
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