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VCU Massey Cancer Center


Suggested grant language

Investigators contemplating the inclusion of core laboratory services in a pending grant application are strongly encouraged to consult with the faculty core director in order to craft grant language tailored to a particular application, and to develop a suitable budget for the proposed services. However, as a starting place, the following language may be used as a template:

“The VCU Structural Biology Core Laboratories, established in 1999, facilitates access to a comprehensive suite of instrumentation and computational resources in support of macromolecular structure determination. There are three main components to the core --X-ray crystallography, Nuclear Magnetic Resonance (NMR), and Molecular Modeling. The subcores are as follows: 1) X-ray crystallography (managers Martin Safo, Ph.D., Tony Wright, Ph.D., and Faik Musayev, Ph.D.) resources include a Rigaku Raxis-IV++ imaging plate system, MicroMax-007 rotating anode, a Blue Max-flux confocal optical system, an x-stream cryogenic system, and a RAXIS-IV++q stage; 2) NMR (manager Neel Scarsdale, Ph.D.) operates a Bruker Avance III 700 MHz instrument (new in 2009) suitable for 1D, 2D, 3D or 4D homo- or hetero-nuclear experiments. The instrument features three RF channels with pulse field gradients, permitting the acquisition of data for triple or pseudo-quadruple resonance experiments; 3) Molecular Modeling (manager Glen Kellog, Ph.D.) is supported by a suite of 8-core ApplePro and HP linux 4 Core graphics workstations, supplemented with a Linux-cluster back-end with over 2000 compute cores provided by the VCU Center for High Performance Computing. Software supported by the Molecular Modeling includes the commercial Tripos Sybl suite, and a number of other packages, including CCP4, GOLD, Dock, AutoDock, HINT, NAMD, Hex, etc.). In addition to instrumentation, the core provides training and consultation, both through formal classes, and one-on-one with individual investigators. The Structural Biology Core laboratory is supported, in part, by funding from the NIH-NCI Cancer Center Support Grant (P30 CA016059)”