Virginia Commonwealth University

VCU Massey Cancer Center

Research

Chat on the current state of cancer treatment and research

Grossman for blog

This past Tuesday ABC News hosted a Twitter chat with the American Association for Cancer Research (AACR) on the current state of cancer following the release of the Cancer Progress Report 2014. Steven R. Grossman, M.D., Ph.D., deputy director of Massey Cancer Center, provided expert commentary as Dr. Richard Besser, ABC News Chief Health/Medical Editor, posed a series of questions and discussion topics. 

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Study uncovers genetic driver of inflammation, uses it to prevent and treat liver cancer

Inflammation has been shown to be a driving force behind many chronic diseases, especially liver cancer, which often develops due to chronic inflammation caused by conditions such as viral hepatitis or alcoholism and has relatively few effective treatment options. Now, scientists at Virginia Commonwealth University Massey Cancer Center have demonstrated for the first time in preclinical studies that blocking the expression of a gene known as astrocyte elevated gene-1 (AEG-1) halts the development and progression of liver cancer by regulating inflammation. This research could impact not only the treatment of liver cancer, but many inflammation-associated diseases.

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New non-invasive technique could revolutionize the imaging of metastatic cancer

Bioluminescence, nanoparticles, gene manipulation – these sound like the ideas of a science fiction writer, but, in fact, they are components of an exciting new approach to imaging local and metastatic tumors. In preclinical animal models of metastatic prostate cancer, scientists at Virginia Commonwealth University Massey Cancer CenterVCU Institute of Molecular Medicine and Johns Hopkins Medical Institutions have provided proof-of-principle of a new molecular imaging approach that could revolutionize doctors’ ability to see tumors that have metastasized to other sites in the body, including the bones.

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Chat on Cancer Pain Management

Recently, the National Cancer Institute hosted a Twitter chat on cancer pain. Patrick Coyne, M.S.N., A.P.R.N., F.A.A.N., clinical director of the Palliative Care Program at VCU Massey Cancer Center and world-renowned pain management specialist, provided expert commentary as the moderator posed a series of questions and discussion topics.  

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Promising new cancer therapy uses molecular “Trash Man” to exploit a common cancer defense

While many scientists are trying to prevent the onset of a cancer defense mechanism known as autophagy, researchers at Virginia Commonwealth University Massey Cancer Center are leveraging it in a new therapy that causes the process to culminate in cell death rather than survival. The novel treatment strategy targets the p62 protein, which is often referred to as the “Trash Man” due to its role in disposing unwanted cellular proteins during autophagy. Results from preclinical experiments suggest this experimental treatment approach could be particularly effective against multiple myeloma and potentially other forms of blood cancers.

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