Protein found to block benefits of vitamin A cancer therapy
Retinoic acid is a form of vitamin A that is used to treat and help prevent the recurrence of a variety of cancers, but for some patients the drug is not effective. The reason for this resistance was unclear until this week when researchers from Virginia Commonwealth University Massey Cancer Center demonstrated that a protein known as AEG-1 blocks the effects of retinoic acid in leukemia and liver cancer. Because AEG-1 is overexpressed in nearly every cancer, these findings could impact the care of countless cancer patients.
Scientists develop mouse model that could lead to new therapies for liver cancer
Researchers have created the first mouse model demonstrating the role of a cancer promoting gene, Astrocyte elevated gene-1 (AEG-1), in hepatocellular carcinoma, or liver cancer. The mouse model represents a critical step in understanding the molecular mechanisms of liver cancer progression and could lead to novel therapies for the disease.
Massey leader Harry Bear appointed to prestigious board
VCU Massey Cancer Center leader and physician-researcher Harry Bear, M.D., Ph.D., has been appointed to serve on the Board of Directors of the NSABP Foundation, Inc. The NSABP – National Surgical Adjuvant Breast and Bowel Project – Foundation is the world’s leading cooperative group for designing and conducting large-scale breast and colorectal cancer clinical trials. Supported by the National Cancer Institute (NCI) since its inception more than 50 years ago, the group has pioneered trials that have changed the way breast and bowel cancers are treated and prevented.
Massey offers microsurgical breast reconstruction
Santosh Kale, MD, plastic surgeon in the Division of Plastic and Reconstructive Surgery at VCU Medical Center and VCU Massey Cancer Center, is one of a few plastic surgeons in the Richmond area to offer microsurgical breast reconstruction. Because of the high level of skill and specialized equipment required to perform microsurgery, this form of breast reconstruction is typically only offered at specialized medical centers such as Massey.
Massey scored highest in Virginia for cancer care by U.S. News for third year
For the third year in a row, VCU Massey Cancer Center was the top scoring hospital in Virginia providing high-performing cancer care in U.S. News & World Report’s annual Best Hospitals list. Massey received the best score in cancer care of the 24 Virginia hospitals that made the list of the nearly 130 total hospitals in the state. Additionally, VCU Medical Center, which includes Massey’s oncology patient care, was ranked the best hospital in the Richmond metro area, marking the fourth consecutive year the hospital has led in the area.